Here we have investigated the expression of SIRT6 in endothelial cells from different vascular beds and explored its function as an anti-senescence gene. Methods SIRT6 mRNA expression was measured by ...

Cellular senescence, where cells permanently stop dividing, plays a complex role in liver health. In a recent review article, ...

Cellular senescence is crucial in processes like ... particularly in macrophages and endothelial cells (ECs), but not in hepatocytes. Flow cytometry and immunostaining further validated that ...

2022). However, whether and how HUVECs-derived endogenous SO 2 affects cell senescence under physiological and pathophysiological conditions remain largely unexplored. A high concentration of glucose ...

Gut microbiota-derived phenylacetylglutamine accelerates aging by driving cellular senescence through mitochondrial ...

The cellular senescence phenotype is heterogeneous and differs between ... it is important to recognize the interactions between cardiomyocytes, endothelial cells, and the mechanisms by which each ...

A new research paper was published in Aging (listed by MEDLINE/PubMed as “Aging (Albany NY)” and “Aging-US” by Web of Science ...

Senescence is the process by which cells irreversibly stop dividing and enter a state of permanent growth arrest without undergoing cell death. Senescence can be induced by unrepaired DNA damage ...

we isolated and expanded blood outgrowth endothelial cells (BOEC) from peripheral blood samples of healthy non-smokers, healthy smokers and COPD patients. Endothelial senescence was measured by ...

Methods VSMCs senescence and senescence-associated secretory phenotype were detected by histological examination, bulk RNA-Seq and single-cell RNA-seq conducted on vascular surgery samples of TAK ...