Yes, Invincibleand Spider-Man have canonically met in a crossover ... In Invincible #33 by Robert Kirkman and Ryan Ottley, Levy has invaded Mark's home, intent on seeking revenge.
The original Invincible comic by Robert Kirkman (The Walking Dead), Cory Walker and Ryan Ottley did a near-perfect tightrope walk between satirizing superhero tropes, playing in them earnestly.