Dec 16, 2020 · Cellular senescence occurs in response to many different triggers, including DNA damage, telomere dysfunction, oncogene activation and organelle stress, and has been linked to processes such as...

May 24, 2024 · Aging is a complex and multifaceted process involving a variety of interrelated molecular mechanisms and cellular systems. Phenotypically, the biological aging process is accompanied by a gradual loss of cellular function and the systemic deterioration of multiple tissues, resulting in susceptibility to aging-related diseases.

Apr 1, 2021 · Under the molecular wear-and-tear paradigm, aging is an unavoidable trait: a fixed expiration date for each organism, set by the specific set of repair mechanisms with a limited capacity to counteract the natural abrasion of cells and tissues.

Here we review a number of crucial processes responsible for regulating cellular health in aging and the link between many of those diseases and aging. Cellular health is controlled at various points in the cell, starting in the nucleus through chromosome structure/organization, transcriptional regulation, and nuclear export/import, ranging ...

Several aging mechanisms have been identified, primarily including genomic instability, telomere shortening, and cellular senescence. Aging is a driving factor of various age-related diseases, including neurodegenerative diseases, cardiovascular diseases, cancer, immune system disorders, and musculoskeletal disorders.

Aging is associated with prolonged changes in cellular mechanical properties (i.e., increased stiffness, decreased elasticity, and reduced strength) in the cardiovascular, musculoskeletal, skin, and immune systems.

Dec 16, 2022 · Cellular senescence, with major effects on the maintenance of normal tissue homeostasis, as well as pathological conditions, is a principle causative factor in the organismal aging process and...

This Review discusses the mechanisms and modulators of cellular senescence establishment and induction of a senescence-associated secretory phenotype, and provides an overview of cellular senescence as an emerging opportunity to intervene through senolytic and senomorphic therapies in ageing and ageing-associated diseases.

Aging can be defined as a state of progressive functional decline accompanied by an increase in mortality. Time-dependent accumulation of cellular damage, namely lesions and mutations in the DNA and misfolded proteins, impair organellar and cellular function.

Mar 28, 2022 · Mechanisms combining both ways of elimination are used in most cases (Michod, 2007; Pichugin et al., 2019). The induction of cellular senescence is an example of such mechanisms occurring in mammals.