GPR40 is highly expressed in β-cells and has turned out to be a key protein mediating free fatty acid potentiation of insulin and an attractive target to enhance insulin secretion in patients with …

Recently, G-protein-coupled receptor 40 (GPR40), a receptor for long-chain fatty acids, was reported to be highly expressed in pancreatic beta cells and involved in the regulation of …

GPR40 has been shown to augment glucose dependent insulin secretion (GDIS) from pancreatic .-cells and is widely studied drug discovery target for the treatment of type 2 diabetes mellitus …

GPR40 is a class A G-protein coupled receptor (GPCR) with conventional 7 transmembrane domains that forms ligand-binding pockets and additional eight helices with a palmitoylated …

GPR40 is no doubt a novel therapeutic target for type 2 diabetes involving mediating insulin secretion, and a series of agonists for GPR40 have developed. However, further studies are …

By signaling predominantly through Gαq/11, GPR40 increases intracellular calcium and activates phospholipases to generate diacylglycerols resulting in increased insulin secretion. Synthetic …

Dec 1, 2016 · Therefore, GPR40 has emerged as a viable and promising therapeutic target for type 2 diabetes mellitus (T2DM) without the risk of hypoglycemia. However, the termination of …

G protein coupling of GPR40 was examined in Chinese hamster ovary cells expressing the Gα q/i -responsive Gal4-Elk1 reporter system. Expression of human GPR40 led to a constitutive …

GPR40 (FFAR1 or FFA1) is a G-protein-coupled receptor (GPCR), primarily expressed in insulin-producing pancreatic β-cells and incretin-producing enteroendocrine cells of the small intestine.

Sep 10, 2021 · GPR40 agonist might exert a positive effect in downregulating the level of cytokines which related to inflammatory progression and ameliorating the insulin resistance in …