Keren JIA | Cited by 225 | of Peking University, Beijing (PKU) | Read 20 publications | Contact Keren JIA

Jul 11, 2022 · CLDN18.2-positive GC displayed unique immune-microenvironmental characteristics, which is of great significance for the development of CLDN18.2-targeted therapies. However, the impact of CLDN18.2-related microenvironmental features on prognosis requires further investigation.

Keren Jia The clinical value of combination of immune checkpoint inhibitors in cancer patients: A meta-analysis of efficacy and safety. International journal of cancer

Aug 20, 2024 · In the KEYNOTE-811 study, anti-HER2 and immunotherapy treatments resulted in longer survival in HER2-positive gastric cancer patients with CPS ≥ 1, whereas CPS < 1 patients lacked notable benefits.

Keren Jia 1 Department of Gastrointestinal Oncology, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Peking University Cancer Hospital & Institute, Beijing, China

We propose a standard pipeline covering sample collection, staining, scanning multispectral images, constructing a spectral library, identifying and phenotyping cells, positioning each element, and quantitatively extracting immune features.

Aug 18, 2022 · To predict the response to immunotherapy, we establish a multi-dimensional TIIC signature by considering the density of CD4 + FoxP3 - PD-L1 +, CD8 + PD-1 - LAG3 -, and CD68 + STING + cells and the spatial organisation of CD8 + PD-1 + LAG3 - T cells.

H. pylori infection is unfavorable for immunotherapy in DNA mismatch repair-deficient/microsatellite instability-high colon adenocarcinoma and esophageal squamous cell cancer. This study highlights the importance of the test for infection in cancer patients treated with immunotherapy.

幽门螺杆菌感染与胃肠道癌症的风险有关；然而，它对胃肠道癌症免疫疗法的影响仍不确定。 北京大学肿瘤医院沈琳团队近期在The Innovation发表一项临床研究，发现幽门螺杆菌感染可能通过塑造“热”肿瘤微环境而成为胃癌免疫治疗的有利因素；但在某些结直肠癌和食管癌患者中，它可能削弱免疫疗法的效果。 总之，该研究揭示了Hp感染对不同胃肠道癌症免疫治疗效果的差异性影响，对于个体化癌症治疗策略的制定具有重要意义。