Jan 12, 2023 · Here we describe a high-affinity human TREM2-activating antibody engineered with a monovalent transferrin receptor (TfR) binding site, termed antibody transport vehicle (ATV), to facilitate...

Sep 28, 2018 · Variations in triggering receptor expressed on myeloid cells 2 (TREM2), one of several genes for which expression is restricted to microglia in the brain, have now been shown to increase the...

In the brain, TREM2 is expressed on microglia that regulate clearance of neuronal debris. [19] Binding of apolipoproteins, such as ApoE, to TREM2 promotes phagocytosis of apoptotic neurons or the uptake of amyloid beta by microglia. [63]

Triggering receptor expressed on myeloid cells-2 (TREM2) mainly expressed on microglia in the brain, and its mutations can increase the risk of Alzheimer's disease (AD).

Apr 18, 2024 · In this study, using high-throughput mass cytometry in the 5×FAD mouse model of amyloidosis, we identified senescent microglia that express high levels of TREM2 but also exhibit a distinct...

We performed gene set analysis (GSA) of pathway scores for the comparison of high AD and TREM2 in each anatomical region (Fig. 7c) and found striking differences between high AD and TREM2 cases, which further showed opposing trends in different brain regions analyzed.

Background Rare TREM2 variants are strong risk factors for Alzheimer’s disease (AD) [1 – 6]. The triggering receptor expressed on myeloid cell 2 (TREM2) gene is situated on chromosome 6, it encodes a transmembrane protein of 230 amino acids, and it is expressed exclusively in microglia within the brain [7].

Excitingly, our preliminary data indicate that TCIP1 can also increase TREM2 levels in the mouse spleen by 24-fold, an organ with a variety of immune cells, including myeloid cells, suggesting its potential to activate TREM2 in other myeloid cells, like brain microglia.

Our analysis addresses four pivotal queries concerning the interrelation of TREM2 with microglial function, Aβ accumulation, tau pathology, and inflammatory processes. However, the diverse inquiries posed yielded inconsistent responses.

5 days ago · Postoperative cognitive dysfunction (POCD) is a prevalent complication in elderly patients, with neuroinflammation identified as a key contributing factor. This study investigates the therapeutic potential of the TREM2-PLCγ2 signaling pathway in mitigating neuroinflammation, neuronal apoptosis and cognitive impairment following surgery. We employed both in vivo and in vitro models to ...