Reactions to blood component transfusion can range from mild to potentially fatal. Transfusion-associated circulatory overload (TACO) is a common transfusion reaction in which pulmonary edema develops primarily due to volume excess or circulatory overload.

Nov 30, 2018 · Highlight transfusion and recipient risk factors for transfusion-associated circulatory overload (TACO) and transfusion-related acute lung injury (TRALI) with an emphasis on patients with hematological malignancies. Describe the contemporary incidence and prevention of TACO and TRALI in relation to mitigation strategies and patient blood management

TACO vs. TRALI B-type Natriuretic Peptide (BNP) • Hormone released from heart with volume expansion in ventricles from pressure overload • BNP <250 pg/mL more consistent with TRALI •Pros: – Easy to measure – Sensitive and specific indicator of cardiogenic pulmonary symptoms – Pre-transfusion to post-transfusion ratio has relatively ...

Patients presenting with shortness of breath and tachypnea immediately after transfusion should increase suspicion of pulmonary complications. With signs of increased pulmonary venous …

Mar 18, 2023 · Transfusion-related acute lung injury (TRALI) is defined as non-cardiogenic pulmonary edema temporally related to transfusion therapy. It tends to occur within 6 hours after a blood transfusion and requires exclusion of other alternative diagnoses such …

Apr 25, 2019 · Transfusion-associated circulatory overload (TACO) and transfusion-related acute lung injury (TRALI) are syndromes of acute respiratory distress that occur within 6 hours of blood transfusion. TACO and TRALI are the leading causes of transfusion-related fatalities, and specific therapies are unavailable.

Ten minutes into blood administration, the patient became acutely hypoxic (SpO2 70%) and hypertensive (200/100 mm Hg). Administration was halted, and a stat chest X-ray (CXR) obtained. Clinical examination was notable for prominent jugular venous distension, unremarkable on …

CXR: B/l infiltrates: B/l infiltrates Clinical Features. Dyspnea, orthopnea, peripheral edema, rapid rise in BP; Differential Diagnosis ... Allergic tranfusion reaction; Transfusion-associated circulatory overload (TACO) Transfusion-related acute lung injury (TRALI) Transfusion-associated graft-versus-host disease; Fluid overload; Sepsis ...

Sep 15, 2023 · When there is a transfusion reaction with acute dyspnea from respiratory distress, acute pulmonary edema with diffuse bilateral infiltrates in the chest x-ray, transfusion-associated circulatory overload (TACO) is in the differential diagnosis.

This is a case highly suggestive of transfusion-associated circulatory overload (TACO). The patient was saturating well on room air prior to the packed red blood cell (PRBC) transfusion. Shortly after completing the PRBC transfusion, the patient developed dyspnea and …