Although senescence plays physiological roles during normal development and it is needed for tissue homeostasis, senescence constitutes a stress response triggered by insults associated with aging such as genomic instability and telomere attrition, …

Nov 24, 2019 · Aging refers to the complex biological process which results in cell death as a result of time, environmental factors, and genetics, while senescence refers to the irreversible form of long-term cell-cycle arrest, caused by excessive intracellular or extracellular stress or …

Aging is the time-related deterioration of the physiological functions necessary for survival and reproduction. The phenotypic changes of senescence (which affect all members of the species) are not to be confused with diseases of senescence, such as cancer and heart disease (which affect individuals).

Dec 16, 2020 · This Review discusses the mechanisms of cellular senescence and induction of a senescence-associated secretory phenotype, recent insights into how senescence contributes to ageing, and the ...

Senescence (/ s ɪ ˈ n ɛ s ə n s /) or biological aging is the gradual deterioration of functional characteristics in living organisms. Whole organism senescence involves an increase in death rates or a decrease in fecundity with increasing age, …

This Review focuses on this and other key emerging concepts in the senescence field, including ‘assisted’ cell cycling, multi-step senescence (or senescence progression), acute versus chronic senescence and senescence of post-mitotic cells.

Here we discuss current progress and challenges in understanding the stressors that induce senescence in vivo, the cell types that are prone to senesce, and the autocrine and paracrine properties of senescent cells in the contexts of aging and …

Jan 2, 2018 · Senescence plays roles in normal development, maintains tissue homeostasis, and limits tumor progression. However, senescence has also been implicated as a major cause of age-related disease. In this regard, recent experimental evidence has shown that the genetic or pharmacological ablation of senescent cells extends life span and improves ...

Oct 15, 2019 · For many of the changes taking place in the body during aging, three factors are important: inflammation, immune aging and senescence (cellular aging, biological aging). Senescence is an irreversible form of long-term cell-cycle arrest, caused by excessive intracellular or extracellular stress or damage.

Feb 26, 2019 · Senescence occurs in three different scenarios: senescence due to normal aging; senescence due to age-related diseases, and senescence induced due to therapy (such as chemotherapy).